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Anxiety, Biopsies, and Waiting: A Recipe for Immune Stress

Waiting Is the Hardest Part
The stress and doubt that accompany the wait for breast biopsy results can lead to undesirable health consequences, according to a study published in the March 2009 issue of Radiology (
•When women express how taxing it is to have to wait for results, the medical establishment may dismiss their feelings as psychological,• said the study's lead author, Elvira V. Lang, M.D. •We were able to show that this state of not knowing the diagnosis goes along with biochemical changes which can have adverse effects on wound healing and the immune system.•
More than 1.2 million breast biopsies are performed in the U.S. annually, with 80 percent resulting in non-cancerous findings, per the American Cancer Society. Dr. Lang and colleagues wanted to establish a biochemical marker to evaluate the physical effects associated with the stress of extended waiting for a final diagnosis after breast biopsy.
For this study, the researchers used cortisol samples collected from the saliva of 126 women during an earlier clinical trial on patient stress during biopsy.  Cortisol is a hormone produced by the adrenal gland and is known as the •stress hormone.•  The production of cortisol is part of the body's natural response to stress.  Stress-induced imbalances in cortisol secretion have been associated with impairments to immune response and wound healing.
•Cortisol helps us fight acute stress by adjusting blood pressure, blood sugar and immune response in a good way when needed,• Dr. Lang said.  •But when stress becomes chronic, cortisol secretion either goes into continuous overdrive or dries up, leaving the immune system vulnerable and other body functions less well adapted.•
Uncertainty: As Stressful as an Actual Malignancy
The women participating in the study underwent large-core breast biopsy and learned their diagnosis one to six days after the procedure.  Salivary cortisol samples were collected on cotton swabs on the day of biopsy and each of the four days following biopsy.
During the period in which the samples were taken, the women learned whether their biopsy results were benign (non-cancerous), malignant (cancerous) or uncertain.  By the fourth day after biopsy, 16 patients had learned they had cancer, 37 patients had benign findings and 73 patients had an uncertain diagnosis, because their results had not been communicated yet or they required further diagnostic procedures.
The results showed that cortisol secretion for the women with uncertain results was significantly different than that of the women with benign results and highly similar to secretion levels in the women with malignant results.
The researchers hope that these findings will encourage faster analysis and communication of biopsy results.  Doctors should speak with women about office communication procedures before the biopsies.
•Women should ask who will communicate their results to them and how long it will take to receive them,• Dr. Lang said.  •Then they should schedule the biopsy accordingly, taking into account delays over weekends and holidays.•

By Chris Navarro
Get Radiology Jobs, Contributing Editor

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